Immunology Core Research

Translational Research

The UCSF Immunology Core supports a large and diverse range of immunological studies encompassing many diseases including studies of autoimmunity (rheumatoid arthritis, psoriasis), psychology (post-traumatic stress disorder, mind-body stress reduction, depression), cancer and trauma. The Immunology Core is also supported, in part, by the Center for AIDS Research and provides extensive support to studies of HIV pathogenesis as well as cure research.

  • Detection of HIV RNA by flow cytometry
  • Detection of NK cell phosphorylation by Phosflow
  • NK cell degranulation and cytokine expression
  • Rare cell flow cytometry for Endothelial Progenitor cells
  • FACS sorting of various immune cell subsets from peripheral blood, mucosal tissue biopsies, lymph nodes, and bone marrow aspirates
  • Immunophenotyping T cell subsets including memory subsets, T regulatory cells, as well as activation and senescent T cell phenotypes

Developmental Research

The Immunology Core's research activities are focused on developing, optimizing, and validating new immunology assays that will support the needs of the UCSF and CFAR research communities. New assays are developed following interaction with investigators.  The laboratory continues to develop and introduce new state-of-the-art flow cytometry panels for immunophenotyping including:

  • Detection of platelets and microparticles by flow cytometry
  • Intracellular detection of cytokines from stimulated monocytes
  • Phosflow for an increased range of phosphorylated targets
  • The Core Immunology Laboratory in collaboration with the Core Virology Laboratory is jointly developing the Tat/rev Induced Limiting Dilution Assay (TILDA) to measure the latent HIV-1 reservoir.
  • Additional areas of focus include:
  • Cryopreservation of mucosal mononuclear cells
  • NK cell Phosflow