Targeting of conserved gag-epitopes in early HIV infection is associated with lower plasma viral load and slower CD4(+) T cell depletion.

AIDS research and human retroviruses

Perez CL, Milush JM, Buggert M, Eriksson EM, Larsen MV, Liegler T, Hartogensis W, Bacchetti P, Lund O, Hecht FM, Nixon DF, Karlsson AC. Targeting of conserved gag-epitopes in early HIV infection is associated with lower plasma viral load and slower CD4(+) T cell depletion. AIDS Res Hum Retroviruses. 2013 Mar; 29(3):602-12.

2013
http://profiles.ucsf.edu/profile/230390
23140171

Perez CL, Milush JM, Buggert M, Eriksson EM, Larsen MV, Liegler T, Hartogensis W, Bacchetti P, Lund O, Hecht FM, Nixon DF, Karlsson AC

Publications

TGF-beta and IL-10 production by HIV-specific CD8+ T cells is regulated by CTLA-4 signaling on CD4+ T cells.

Elrefaei M, Burke CM, Baker CA, Jones NG, Bousheri S, Bangsberg DR, Cao H

2009
Functionally distinct subsets of human NK cells and monocyte/DC-like cells identified by coexpression of CD56, CD7, and CD4.

Milush JM, Long BR, Snyder-Cappione JE, Cappione AJ, York VA, Ndhlovu LC, Lanier LL, Michaëlsson J, Nixon DF

2009
Functionally distinct subsets of human NK cells and monocyte/DC-like cells identified by coexpression of CD56, CD7, and CD4.

Milush JM, Long BR, Snyder-Cappione JE, Cappione AJ, York VA, Ndhlovu LC, Lanier LL, Michaëlsson J, Nixon DF

2009
P03-09. Preserved adaptive immune responses and limited immune activation in CD4-low SIV-positive sooty mangabeys.

KD Mir, JM Milush, JM Brenchley, JD Reeves, SN Gordon, JG Else, E O'Neill, G Silvestri, DL Sodora

2009
Elevated levels of innate immune modulators in lymph nodes and blood are associated with more-rapid disease progression in simian immunodeficiency virus-infected monkeys.

Durudas A, Milush JM, Chen HL, Engram JC, Silvestri G, Sodora DL

2009
Elevated levels of innate immune modulators in lymph nodes and blood are associated with more-rapid disease progression in simian immunodeficiency virus-infected monkeys.

Durudas A, Milush JM, Chen HL, Engram JC, Silvestri G, Sodora DL

2009
AIDSVAX immunization induces HIV-specific CD8+ T-cell responses in high-risk, HIV-negative volunteers who subsequently acquire HIV infection.

Jones NG, DeCamp A, Gilbert P, Peterson ML, Gurwith M, Cao H

2008
Gamma/Delta T cell mRNA levels decrease at mucosal sites and increase at lymphoid sites following an oral SIV infection of macaques.

Kosub DA, Durudas A, Lehrman G, Milush JM, Cano CA, Jain MK, Sodora DL

2008
Gamma/Delta T cell mRNA levels decrease at mucosal sites and increase at lymphoid sites following an oral SIV infection of macaques.

Kosub DA, Durudas A, Lehrman G, Milush JM, Cano CA, Jain MK, Sodora DL

2008
Presence of suppressor HIV-specific CD8+ T cells is associated with increased PD-1 expression on effector CD8+ T cells.

Elrefaei M, Baker CA, Jones NG, Bangsberg DR, Cao H

2008
HIV subtypes induce distinct profiles of HIV-specific CD8(+) T cell responses.

Baker CA, McEvers K, Byaruhanga R, Mulindwa R, Atwine D, Nantiba J, Jones NG, Ssewanyana I, Cao H

2008
Gamma/Delta T-cell functional responses differ after pathogenic human immunodeficiency virus and nonpathogenic simian immunodeficiency virus infections.

Kosub DA, Lehrman G, Milush JM, Zhou D, Chacko E, Leone A, Gordon S, Silvestri G, Else JG, Keiser P, Jain MK, Sodora DL

2007
Gamma/Delta T-cell functional responses differ after pathogenic human immunodeficiency virus and nonpathogenic simian immunodeficiency virus infections.

Kosub DA, Lehrman G, Milush JM, Zhou D, Chacko E, Leone A, Gordon S, Silvestri G, Else JG, Keiser P, Jain MK, Sodora DL

2007
Pattern of malaria-specific T-cell responses in a cohort of Ugandan children.

Ssewanyana I, Pietras C, Baker CA, Nghania F, Jones NG, Rosenthal PJ, Dorsey G, Cao H

2007
Profile of T cell immune responses in HIV-infected children from Uganda.

Ssewanyana I, Elrefaei M, Dorsey G, Ruel T, Jones NG, Gasasira A, Kamya M, Nakiwala J, Achan J, Charlebois E, Havlir D, Cao H

2007
Severe depletion of mucosal CD4+ T cells in AIDS-free simian immunodeficiency virus-infected sooty mangabeys.

Gordon SN, Klatt NR, Bosinger SE, Brenchley JM, Milush JM, Engram JC, Dunham RM, Paiardini M, Klucking S, Danesh A, Strobert EA, Apetrei C, Pandrea IV, Kelvin D, Douek DC, Staprans SI, Sodora DL, Silvestri G

2007
Virally induced CD4+ T cell depletion is not sufficient to induce AIDS in a natural host.

Milush JM, Reeves JD, Gordon SN, Zhou D, Muthukumar A, Kosub DA, Chacko E, Giavedoni LD, Ibegbu CC, Cole KS, Miamidian JL, Paiardini M, Barry AP, Staprans SI, Silvestri G, Sodora DL

2007
Severe depletion of mucosal CD4+ T cells in AIDS-free simian immunodeficiency virus-infected sooty mangabeys.

Gordon SN, Klatt NR, Bosinger SE, Brenchley JM, Milush JM, Engram JC, Dunham RM, Paiardini M, Klucking S, Danesh A, Strobert EA, Apetrei C, Pandrea IV, Kelvin D, Douek DC, Staprans SI, Sodora DL, Silvestri G

2007
Virally induced CD4+ T cell depletion is not sufficient to induce AIDS in a natural host.

Milush JM, Reeves JD, Gordon SN, Zhou D, Muthukumar A, Kosub DA, Chacko E, Giavedoni LD, Ibegbu CC, Cole KS, Miamidian JL, Paiardini M, Barry AP, Staprans SI, Silvestri G, Sodora DL

2007
HIV Subtypes Distribution and Implication for Antiretroviral Treatment in a Ugandan Population.

Baker CA, Bousheri S, Ssewanyana I, Jones NG, K'Aluoch O, Baliruno D, Ssali F, Cao H

2007